GHRP-6

Growth Hormone-Releasing Peptide-6 (GHRP-6) Acetate
His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
C₄₆H₅₆N₁₂O₆
Mechanism of Action
• Growth Hormone Release: GHRP-6 is a synthetic growth hormone-releasing peptide that stimulates the secretion of growth hormone (GH) from the anterior pituitary gland by activating the growth hormone secretagogue receptor (GHSR). This mechanism is distinct from that of growth hormone-releasing hormone (GHRH), as GHRP-6 primarily promotes GH release through GHSR activation.
• Appetite Regulation: GHRP-6 also regulates appetite by activating the GHSR in the hypothalamus, leading to increased hunger and food intake. This effect is partly mediated by the activation of neuropeptide Y (NPY) release in the hypothalamus.
• Metabolic Regulation: GHRP-6 can modulate various metabolic processes, including promoting lipolysis and increasing muscle protein synthesis, which helps to improve body composition.
Physiological and Pharmacological Effects
• Muscle Growth: By promoting the release of growth hormone, GHRP-6 increases muscle protein synthesis and supports muscle growth and repair.
• Lipolysis: GHRP-6 promotes the breakdown of fat, reducing body fat, particularly in the abdominal area.
• Increased Bone Density: The release of growth hormone aids in increasing bone density and preventing osteoporosis.
• Anti-aging: By maintaining higher levels of growth hormone, GHRP-6 helps to delay the aging process, improving skin elasticity and reducing wrinkles.
• Immune System Regulation: The release of growth hormone also enhances the function of the immune system, boosting the body’s resistance to infections.