DR

Mechanism of Action
• Opioid Receptor Agonist: Dermorphin acts as a potent agonist at the μ-opioid receptor (MOR), which is primarily responsible for its analgesic effects. Activation of the μ-opioid receptor leads to the inhibition of adenylate cyclase, a decrease in cyclic AMP (cAMP) levels, and subsequent modulation of ion channels, resulting in reduced neuronal excitability and pain perception.
• High Potency: Due to its high affinity for the μ-opioid receptor, dermorphin is significantly more potent than morphine, making it a potential candidate for pain management therapies.
• Pain Management: Given its high potency and analgesic properties, dermorphin has been studied for its potential use in managing severe pain conditions. Its rapid onset of action and strong binding affinity make it an attractive candidate for acute pain relief.
• Research Tool: Dermorphin is also used as a research tool to study the structure and function of opioid receptors. Its high potency and selectivity for the μ-opioid receptor allow researchers to investigate the mechanisms of opioid action and develop new analgesic agents.
• Drug Development: The study of dermorphin has contributed to the development of new opioid analgesics with improved efficacy and reduced side effects. Its structure has inspired the design of synthetic analogs with enhanced stability and reduced potential for abuse.